Literature Display

Article 1- Estradiol induced endoplasmic reticulum stress inhibition normalizes splenic CD4+T lymphocytes after hemorrhagic shock

Literature link：https://www.nature.com/articles/s41598-021-87159-1

Article Title：Estradiol-induced inhibition of endoplasmic reticulum stress normalizes splenic CD4 + T lymphocytes following hemorrhagic shock

Journal Publication：Scientific Reports

impact factor（IF）：4.149

DOI:https://doi.org/10.1038/s41598-021-87159-1

Article Topic：The main study investigated the activation of 17 β - estradiol (E2)/estrogen receptor (ER) by inhibiting endoplasmic reticulum stress (ERS) after hemorrhage, which normalizes the proliferation of splenic CD4+T lymphocytes and cytokine production. Hemorrhagic shock (femoral artery bleeding, 38-42 mmHg for 90 minutes, followed by resuscitation for 30 minutes, and observation period for 180 minutes) reduces CD4 levels; +After isolation and incubation with concanavalin A (5 μ g/mL) for 48 hours, T lymphocyte proliferation and cytokine production were induced, leading to spleen injury, loss of white pulp contour, irregular cell structure, typical inflammatory cell infiltration, and upregulation of ERS biomarker 78 kDa glucose regulatory protein (GRP78) and activated transcription factor 6 (ATF6) expression. Administration of E2, ER - α agonist propiconazole triol (PPT) or ERS inhibitor 4-phenylbutyric acid normalized these parameters, while administration of ER - β agonist diarylpropionitrile had no effect. In contrast, the administration of ERs antagonists ICI 182780 or G15 eliminated the beneficial effects of E2. Similarly, the ERS inducer erythromycin caused side effects similar to hemorrhagic shock and exacerbated the effects of shock in sham rats, and also cancelled the beneficial effects of E2 and PPT, respectively.

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The Second Article——The relationship between thymosin beta-4, acute kidney injury, and mortality in sepsis patients: an observational study

Literature link：https://www.sciencedirect.com/science/article/pii/S1567576921008031?via%3Dihub

Article Title：Association between Thymosin beta-4, acute kidney injury, and mortality in patients with sepsis: An observational cohort study

Journal Publication：International Immunopharmacology

impact factor（IF）：4.932

DOI:https://doi.org/10.1016/j.intimp.2021.108167

Article Topic：      Prospective measurements of T β 4 concentration were conducted on 191 patients diagnosed with sepsis within 6 hours of admission to the intensive care unit (ICU). The results showed that among 191 patients, 92 developed AKI, of which 24 received continuous renal replacement therapy (CRRT), 29 patients died within 7 days, and 53 patients died within 28 days. A lower T β 4 stage is associated with poor prognosis. Kaplan Meier analysis found that patients with lower T β 4 levels have a higher risk of developing AKI and death. The lower the T β 4 staging, the higher the likelihood of poor prognosis in ICU sepsis patients.

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