• March is a poem written with sunshine, bright and warm;

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• Hello March!
  

We have compiled the high scoring literature on the Gene Beauty brand test kit in February and summarized it as follows.

Literature Display

The first article: There is a positive correlation between circulating cadmium and epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease

Article Title：Circulatory cadmium positively correlates with epithelial-mesenchymal transition in patients with chronic obstructive pulmonary disease

Journal Publication：Ecotoxicol Environ Saf

impact factor（IF）：4.872

DOI:https://doi.org/10.1016/j.ecoenv.2021.112164

Article Topic：    This study analyzed the relationship between circulating cadmium, epithelial mesenchymal transition (EMT), and lung function in patients with chronic obstructive pulmonary disease (COPD). The results showed that the circulating cadmium concentration in COPD patients increased, and the circulating cadmium concentration in COPD patients was negatively correlated with lung function; MiR-30 in the serum of COPD patients is reduced, while EMT in lung tissue is increased; The circulating cadmium concentration in COPD patients is negatively correlated with serum miR-30 and positively correlated with EMT. In vitro experiments have shown that cadmium exposure downregulates miR-30 levels in human lung epithelial cells and upregulates EMT. The decrease of miR-30 contributes to pulmonary EMT and may be involved in the process of cadmium induced COPD in the environment.

The Second Article——serumS100A8As an early diagnostic biomarker for community-acquired pneumonia patients

Article Title：Serum S100A8 as an early diagnostic biomarker in patients with community-acquired pneumonia

Journal Publication：Arch Med Sci

impact factor（IF）：2.807

DOI:10.5114/aoms/130648

Article Topic：  The aim of this study is to analyze the relationship between serum S100A8 and the severity of community-acquired pneumonia (CAP). The results showed that serum S100A8 was elevated in CAP patients upon admission, and serum S100A8 was positively correlated with CAP severity score, blood routine parameters, and inflammatory cytokines; In addition, knocking down the S100A8 gene can alleviate the inflammatory factors induced by Streptococcus pneumoniae in A549 cells. S100A8 may be involved in the occurrence and development of CAP, and has a significant impact on the pathophysiology of CAP. It can be used as an early serum diagnostic marker for CAP and may become a therapeutic target for CAP in future clinical applications.

Part Three——serum8-iso-PGF2αPredicting the severity and prognosis of community-acquired pneumonia patients: a retrospective cohort study

Article Title：Serum 8-iso-PGF2α Predicts the Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study

Journal Publication：Frontiers in Medicine

impact factor（IF）：3.9

DOI: 10.3389/fmed.2021.633442

Article Topic： The main objective of this study is to investigate the correlation between serum 8-iso-PGF2 α and severity and prognosis in patients with community-acquired pneumonia (CAP) through a retrospective cohort study based on hospitals. This study included 220 patients with CAP, and the results showed that serum 8-iso-PGF2 α levels were positively correlated with CAP severity score and circulating inflammatory cytokines (CRP and TNF α); The higher the serum level of 8-iso-PGF2 α upon admission, the longer the hospital stay and the higher the risk of death for CAP patients. 8-iso-PGF2 α may be involved in the progression of CAP and can serve as an early serum prognostic biomarker and potential therapeutic target for CAP.