The sky in November may be shrouded in leaden clouds, misty rain, or endless sandstorms,

When the wind clears and the rain rests, the sun rises and the clouds open, naturally bright and clear.

Although we reside in far corners of the world, having a good friend is akin to having a good neighbor.

Although gatherings and separations may occur at times, thoughts often linger.

In November, meeting each other is like meeting for the first time.

We have compiled the high scoring literature on the Gene Beauty brand test kit in October and summarized it as follows.

Literature Display

The first article - The scar reducing effect of oxalic acid on rabbit ear skin wounds

Article Title：Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears

Journal Publication：International Immunopharmacology

impact factor（IF）：4.932

Affiliation：Anhui Medical University

DOI: https://doi.org/10.1016/j.intimp.2020.107200

Article Topic：

This study used different methods to detect the scar hypertrophy index (SEI), expression of type I collagen (Col-I) and type III collagen (Col-III), microvascular density (MVD), infiltration of CD4+T cells and macrophages, expression levels of vascular endothelial growth factor receptor 2 (VEGFR2), fibroblast growth factor receptor 1 (FGFR1), p-VEGFR2, p-FGFR1, IL-1 β, IL-6, IL-10, TNF - α, TGF - β 1, and connective tissue growth factor (CTGF) in scar tissue. It was found that quercetin significantly reduced the expression of SEI, Col-I, and Col-III in scar tissue in a concentration dependent manner; Reduce MVD in scar tissue; Inhibit CD4+T cell and macrophage infiltration; Reduce the levels of VEGFR2, p-VEGFR2, FGFR1, p-FGFR1, TGF - β 1, CTGF, IL-1 β, IL-6, and TNF - α; Upregulation of IL-10 levels. This indicates that quercetin can reduce the formation of hypertrophic scars in scar tissue, and its mechanism is related to the inhibition of neovascularization, local inflammatory response, and growth factor expression in scar tissue during wound healing.

This study suggests that ferulic acid can be used as a preventive and therapeutic drug for hypertrophic scars.

The second article - Zinc oxide nanoparticles through reactive oxygen species andCaspaseSignal pathway induces apoptosis of human tendon fibroblasts

Article Title：Zinc oxide nanoparticles induce human tenon fibroblast apoptosis through reactive oxygen species and caspase signaling pathway

Journal Publication：Arch Biochem Biophys

impact factor（IF）：4.013

Affiliation：Jining Medical University; Jining First People's Hospital

DOI: https://doi.org/10.1016/j.abb.2020.108324

Article Topic：

This study investigated the effects of zinc oxide nanoparticles on reactive oxygen species (ROS) and mitochondrial membrane potential (Δ ψ m) in human tendon fibroblasts (HTFs). In addition, the effects of zinc oxide nanoparticles on the expression of Caspase-3, Caspase-9, APAF-1, FSP-1, Col III, and E-cadherin were also investigated. It was found that zinc oxide nanoparticles significantly inhibited the activity of HTFs, reduced Δ ψ m, induced the expression of Caspase-3, Caspase-9, and APAF-1 in HTFs, inhibited the expression of FSP-1, Col III, and E-cadherin, and promoted HTFs apoptosis.

This study suggests that the potential mechanism by which zinc oxide nanoparticles induce apoptosis in HTFs is closely related to the increase in ROS and activation of the Caspase signaling pathway.